澳门新葡新京,澳门新葡新京官方网站

化苑讲坛

美国俄亥俄州立大学Carlos Castro副教授做客第421期化苑讲坛

编辑:  发布:2019-06-03 15:22:18  点击量:

报告题目Design, control, and applications of DNA nanomechanical devices

人:Prof. Carlos Castro

报告时间:201964日(周二)下午3:00

报告地点:化学楼一号会议室

人:吴钰周教授

报告人概况:

Carlos     Castro,俄亥俄州立大学机械航天工程系副教授。2009年在美国麻省理工学院机械工程系获博士学位,2011年在洪堡基金资助下于慕尼黑工业大学完成博士后研究。  

主要从事DNA纳米机器人、DNA纳米机械装置的制造及在生物医学工程中的应用等研究,在Advanced MaterialsACS Nano等国际期刊发表文章30余篇。

报告概况:

Structural DNA nanotechnology is a rapidly emerging field with exciting potential for applications such as single molecule sensing, drug delivery, and manipulating molecular components. However, realizing the functional potential of DNA nanomachines, and ultimately nanorobots, requires the ability to design dynamic mechanical behavior such as complex motion, conformational dynamics, or force generation. Our lab has developed approaches to design and construct DNA nanostructures with programmable 1D, 2D, and 3D motion as well as dynamic nanostructures with programmed or externally controlled conformational  dynamics.  We  have also recently developed methods to manipulate dynamic DNA nanodevices  via  external  magnetic fields. This approach relies on coupling the motion of micron-scale magnetic beads to nanoscale DNA machines via a long mechanical lever arm made from an array of highly stiff DNA origami structures. We demonstrated the ability to drive continuous or oscillating rotational motions of nanoscale devices up to several Hz. Moving forward, we aim to develop devices  where nanoscale dynamic behavior (i.e. motion, conformational distributions, and kinetics) can  be exploited to probe physical properties or manipulate nanoscale components or molecular interactions in real time. I will also highlight two ongoing projects in our lab implementing DNA nanodevices to probe the structure and dynamics of nucleosomes and to engineer cell surface functions such as intercellular adhesion and biomolecule sensing.

Copyright ©版权所有:门新葡新京 2014-2021
地址:武汉市洪山区珞喻路1037号澳门新葡新京官方网站化学楼  
邮编:430074

  • 微信公众号

XML 地图 | Sitemap 地图
XML 地图 | Sitemap 地图